Are cytochrome P450 3A enzymes in the small intestine responsible for different cyclosporine metabolite patterns in stable male and female renal allograft recipients after co-administration of diltiazem?

Transplant Proc. 1996 Aug;28(4):2159-61.

Authors

U Christians¹, J S Bleck, A Lampen, A Bader, C Thiesemann, V Kliem, H Repp, M Westhoff-Bleck, M Manns, K F Sewing

Affiliation

¹ Institut für Allgemeine Pharmakologie, Medizinische Hochschule Hannover, Germany.

PMID: 8769186

No abstract available

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Calcium Channel Blockers / pharmacology*
Cyclosporine / metabolism*
Cyclosporine / pharmacokinetics
Cyclosporine / therapeutic use
Cytochrome P-450 CYP2E1
Cytochrome P-450 Enzyme System / metabolism*
Diltiazem / pharmacology*
Duodenum
Female
Humans
Immunosuppressive Agents / metabolism*
Immunosuppressive Agents / pharmacokinetics
Immunosuppressive Agents / therapeutic use
Intestinal Mucosa / enzymology*
Kidney Transplantation* / immunology
Male
Metabolic Clearance Rate
Microsomes / enzymology
Middle Aged
Mixed Function Oxygenases / metabolism*
Sex Characteristics

Substances

Calcium Channel Blockers
Immunosuppressive Agents
Cyclosporine
Cytochrome P-450 Enzyme System
Mixed Function Oxygenases
Cytochrome P-450 CYP2E1
Diltiazem