Hepatitis C virus types 7, 8 and 9 should be classified as type 6 subtypes

J Hepatol. 1996 May;24(5):622-4. doi: 10.1016/s0168-8278(96)80149-8.

Abstract

Tokita et al. reported the identification of hepatitis C virus type 7, 8 and 9 in Southeast Asia, based on the unweighed pair-group method with the arithmetic mean, a method that may not be appropriate when the nucleotide substitution rate is not constant over time. To determine more accurately the relationship of these proposed types 7, 8, and 9 with other types, a more appropriate approach, the neighbor-joining method, was applied to re-evaluate the phylogenetic relationship. A total of 660 HCV sequences, including the reported sequences, were collected from DNA databases. For every region, the nucleotide substitution rate was estimated by the 6-parameter method, and phylogenetic trees were constructed using the neighbor-joining method. The results of this analysis indicate that the newly proposed HCV types 7, 8 and 9 should be classified as type 6 subtypes. HCV type 6 appears to be diversified.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Evolution, Chemical
  • Hepacivirus / classification*
  • Nucleotides / chemistry*
  • Phylogeny*

Substances

  • Nucleotides