Acute respiratory distress syndrome due to methicillin-resistant Staphylococcus aureus sepsis in hyper-IgE syndrome

Eur Respir J. 1996 Feb;9(2):386-8. doi: 10.1183/09031936.96.09020386.

Abstract

We report the case of a 34 year old woman with acute respiratory distress syndrome (ARDS) and disseminated intravascular coagulation (DIC) due to methicillin-resistant Staphylococcus aureus (MRSA) sepsis with hyperimmunoglobulin E syndrome (HIES). Although chemotactic activity of neutrophils was impaired in this patient, neutrophils accumulated in the lungs as assessed by bronchoalveolar lavage fluid (BALF) counts. In addition to antibiotics and oxygen therapy, the administration of recombinant human granulocyte colony-stimulating factor (rhG-CSF) resulted in a remarkable recovery.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Adult
  • Anti-Bacterial Agents / therapeutic use
  • Anti-Inflammatory Agents / therapeutic use
  • Bacteremia / complications*
  • Bacteremia / diagnosis
  • Bacteremia / drug therapy
  • Disseminated Intravascular Coagulation / diagnosis
  • Disseminated Intravascular Coagulation / drug therapy
  • Disseminated Intravascular Coagulation / etiology
  • Female
  • Humans
  • Infant, Newborn
  • Job Syndrome / complications*
  • Job Syndrome / diagnosis
  • Job Syndrome / drug therapy
  • Methicillin / therapeutic use
  • Methicillin Resistance*
  • Methylprednisolone / therapeutic use
  • Respiratory Distress Syndrome, Newborn / diagnosis
  • Respiratory Distress Syndrome, Newborn / drug therapy
  • Respiratory Distress Syndrome, Newborn / microbiology*
  • Serine Proteinase Inhibitors / therapeutic use
  • Staphylococcal Infections / complications*
  • Staphylococcal Infections / diagnosis
  • Staphylococcal Infections / drug therapy
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / isolation & purification

Substances

  • Anti-Bacterial Agents
  • Anti-Inflammatory Agents
  • Serine Proteinase Inhibitors
  • Methicillin
  • Methylprednisolone