Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase

H D Sun; S X Qiu; L Z Lin; Z Y Wang; Z W Lin; T Pengsuparp; J M Pezzuto; H H Fong; G A Cordell; N R Farnsworth

doi:10.1021/np960149h

Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase

J Nat Prod. 1996 May;59(5):525-7. doi: 10.1021/np960149h.

Authors

H D Sun¹, S X Qiu, L Z Lin, Z Y Wang, Z W Lin, T Pengsuparp, J M Pezzuto, H H Fong, G A Cordell, N R Farnsworth

Affiliation

¹ Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, People's Republic of China.

PMID: 8778243
DOI: 10.1021/np960149h

Abstract

An A ring-secocycloartene triterpenoid, nigranoic acid (3,4-secocycloarta-4(28),24-(Z)-diene-3,-26-dioic acid, (1) was isolated from the stems of Schisandra sphaerandra, a Chinese traditional medicinal plant. Its structure elucidation and unambiguous NMR spectral assignment were achieved by the combination of 1D- and 2D-NMR techniques with the aid of computer modeling. Nigranoic acid showed activity in several anti-HIV reverse transcriptase and polymerase assays.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

China
HIV Reverse Transcriptase
Humans
Magnetic Resonance Spectroscopy
Nucleic Acid Synthesis Inhibitors
Plants, Medicinal / chemistry*
RNA-Directed DNA Polymerase / metabolism*
Reverse Transcriptase Inhibitors / isolation & purification*
Reverse Transcriptase Inhibitors / pharmacology*
Triterpenes / isolation & purification*
Triterpenes / pharmacology

Substances

Nucleic Acid Synthesis Inhibitors
Reverse Transcriptase Inhibitors
Triterpenes
nigranoic acid
HIV Reverse Transcriptase
RNA-Directed DNA Polymerase