Abstract
Trigeminothalamic and spinothalamic-tract neurons provided with substance P receptor (SPR) were examined in the rat by SPR immunofluorescence histochemistry combined with Fluoro-Gold (FG) fluorescent retrograde labeling. After FG injection in the thalamic regions, FG-labeled cells with SPR-like immunoreactivity were seen mainly in laminae I and III of the medullary and spinal dorsal horns and lateral spinal nucleus. In these regions, about one-fourth to one-third of FG-labeled cells showed SPR-like immunoreactivity.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Afferent Pathways / physiology
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Animals
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Fluorescent Antibody Technique
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Fluorescent Dyes
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Histocytochemistry
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Male
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Neurons / chemistry*
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Pain / physiopathology*
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Rats
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Rats, Wistar
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Receptors, Neurokinin-1 / analysis*
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Spinothalamic Tracts / chemistry*
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Spinothalamic Tracts / cytology
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Stilbamidines*
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Thalamus / chemistry*
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Thalamus / cytology
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Trigeminal Ganglion / chemistry*
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Trigeminal Ganglion / cytology
Substances
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2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt
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Fluorescent Dyes
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Receptors, Neurokinin-1
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Stilbamidines