Abstract
A commercially available test for the serologic diagnosis of tuberculosis was evaluated for its applicability in human immunodeficiency virus (HIV)-positive patients. Antibodies to lipoarabinomannan were detectable in sera from only 9 of 85 HIV-positive patients with a confirmed diagnosis of tuberculosis. Given the low degree of sensitivity of the assay with sera from HIV-infected patients, the study does not support the use of this serologic assay for the diagnosis of tuberculosis in HIV-infected patients.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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AIDS-Related Opportunistic Infections / complications
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AIDS-Related Opportunistic Infections / diagnosis
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AIDS-Related Opportunistic Infections / immunology*
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Antibodies, Bacterial / blood*
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Antigens, Bacterial
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Case-Control Studies
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Cohort Studies
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Evaluation Studies as Topic
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False Negative Reactions
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Humans
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Lipopolysaccharides / immunology*
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Mycobacterium Infections / complications
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Mycobacterium Infections / diagnosis
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Mycobacterium Infections / immunology
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Sensitivity and Specificity
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Serologic Tests / methods
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Serologic Tests / statistics & numerical data
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Tuberculosis, Pulmonary / complications
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Tuberculosis, Pulmonary / diagnosis
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Tuberculosis, Pulmonary / immunology*
Substances
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Antibodies, Bacterial
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Antigens, Bacterial
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Lipopolysaccharides
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lipoarabinomannan