Abstract
A rat immunogenicity assay for IPV potency was validated and applied to routine vaccine testing as a potential alternative to the CFR Monkey Potency Assay. Potencies of pure trivalent polio, various combinations and experimental vaccines were tested with a view of producing a single dilution assay.
MeSH terms
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Animal Testing Alternatives / methods*
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Animal Testing Alternatives / standards
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Animals
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Macaca fascicularis
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Poliovirus Vaccine, Inactivated / analysis
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Poliovirus Vaccine, Inactivated / immunology*
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Poliovirus Vaccine, Inactivated / standards
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Rats
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Reference Standards
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Reproducibility of Results
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Sensitivity and Specificity
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United States
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Vaccines, Inactivated / analysis
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Vaccines, Inactivated / immunology
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Vaccines, Inactivated / standards
Substances
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Poliovirus Vaccine, Inactivated
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Vaccines, Inactivated