Abstract
PIC 024-4 and PRO 2000 are naphthalene sulfonate polymers that bind to CD4 with nanomolar affinity and block binding of gp120. Both have activity against human immunodeficiency virus type 1 in H9 cells, peripheral blood mononuclear cells, and primary monocyte/macrophages, are synergistic with zidovudine, and do not inhibit tetanus toxoid-stimulated T-cell proliferation at anti-human immunodeficiency virus type 1 concentrations.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antiviral Agents / pharmacology*
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Binding, Competitive
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CD4 Antigens / drug effects*
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CD4-Positive T-Lymphocytes / drug effects
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Cell Line, Transformed
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HIV Envelope Protein gp120 / drug effects*
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HIV-1 / drug effects*
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Humans
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Macaca fascicularis
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Naphthalenesulfonates / pharmacology*
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Naphthalenesulfonates / toxicity
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Polymers / pharmacology
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Protein Binding / drug effects
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Rats
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Recombinant Proteins / drug effects
Substances
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Antiviral Agents
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CD4 Antigens
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HIV Envelope Protein gp120
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Naphthalenesulfonates
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Polymers
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Recombinant Proteins