Statistical properties of the allelic and genotypic transmission/disequilibrium test for multiallelic markers

Genet Epidemiol. 1995;12(6):865-70. doi: 10.1002/gepi.1370120656.

Abstract

The transmission/disequilibrium test (TDT) is extended in two ways for a multiallelic marker: (1) to compare transmitted and nontransmitted alleles from a single heterozygous parent and (2) to compare genotypes formed by the two transmitted alleles and genotypes formed by the two nontransmitted alleles using the information on both parents, heterozygous or not, simultaneously.

Publication types

  • Comparative Study

MeSH terms

  • Alleles
  • Female
  • Gene Frequency*
  • Genetic Diseases, Inborn / genetics*
  • Genetic Markers*
  • Genotype
  • Heterozygote
  • Humans
  • Linkage Disequilibrium*
  • Male
  • Models, Genetic
  • Models, Statistical*
  • Nuclear Family*

Substances

  • Genetic Markers