Enantiospecific inhibition of emesis induced by nicotine in the house musk shrew (Suncus murinus) by the neurokinin1 (NK1) receptor antagonist CP-99,994

Neuropharmacology. 1995 Dec;34(12):1697-9. doi: 10.1016/0028-3908(95)00164-6.

Abstract

Effects of the NK1 receptor antagonist CP-99,994 on nicotine-induced emesis were examined in Suncus murinus. CP-99,994 (3 and 10 mg/kg i.p.) attenuated emesis to (-)nicotine (4 mg/kg s.c.). CP-100,263 (3 and 10 mg/kg i.p.), the enantiomer of CP-99,994 with 1000 fold lower affinity for the NK1 receptor was without effect and RP67580 reduced emesis only at a dose of 30 mg/kg i.p. Responses to NK1 antagonists were ranked according to their affinities for the Suncus murinus NK1 receptor.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Antiemetics / pharmacology*
  • Dose-Response Relationship, Drug
  • Indoles / pharmacology
  • Isoindoles
  • Male
  • Morphine / pharmacology
  • Neurokinin A / antagonists & inhibitors*
  • Nicotine
  • Piperidines / pharmacology*
  • Receptors, Neurokinin-1 / drug effects*
  • Shrews
  • Stereoisomerism
  • Substance P / antagonists & inhibitors
  • Vomiting / chemically induced
  • Vomiting / prevention & control*

Substances

  • Antiemetics
  • Indoles
  • Isoindoles
  • Piperidines
  • Receptors, Neurokinin-1
  • 7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one
  • 3-(2-methoxybenzylamino)-2-phenylpiperidine
  • Substance P
  • Nicotine
  • Morphine
  • Neurokinin A