Aspergillus laryngotracheobronchitis presenting as stridor in a patient with peripheral T cell lymphoma

Thorax. 1996 Aug;51(8):869-70. doi: 10.1136/thx.51.8.869.

Abstract

Invasive aspergillosis is a serious opportunistic infection in immunocompromised patients. The case history is described of a 44 year old patient with peripheral T cell lymphoma who developed hoarseness and stridor after chemotherapy. Aspergillus fumigatus was isolated repeatedly from the sputum. Bronchoscopic examination showed symmetrical creamy-white exophytic lesions involving both vocal cords and the supraglottic area. There was diffuse tracheobronchitis with multiple raised cream-coloured plaques in the trachea which histologically consisted of numerous septate branching hyphae consistent with Aspergillus species. The lesions responded to systemic treatment with amphotericin B.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Amphotericin B / therapeutic use
  • Aspergillosis / complications*
  • Aspergillosis / drug therapy
  • Aspergillus fumigatus*
  • Bronchitis / microbiology
  • Humans
  • Itraconazole / therapeutic use
  • Laryngitis / microbiology
  • Lymphoma, T-Cell, Peripheral / complications*
  • Lymphoma, T-Cell, Peripheral / microbiology
  • Male
  • Respiratory Sounds / etiology*
  • Respiratory Tract Infections / complications*
  • Respiratory Tract Infections / microbiology
  • Tracheitis / microbiology

Substances

  • Itraconazole
  • Amphotericin B