Abstract
Here, we report a mutation screening by single-stranded conformational analysis of the astroglial human brain glutamate transporter (HBGT) II complementary DNA in patients with amyotrophic lateral sclerosis. The conformational analysis data indicate a lack of sequence variations in the HBGT II coding region in 6 patients with amyotrophic lateral sclerosis and the same number of nonneurological control subjects. In both groups, three variants of the HBGT II 5' untranslated region were isolated. We have no evidence that the reported complementary DNA variants are disease specific.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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ATP-Binding Cassette Transporters / genetics*
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Aged
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Amino Acid Transport System X-AG
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Amyotrophic Lateral Sclerosis / genetics*
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Amyotrophic Lateral Sclerosis / metabolism*
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Base Sequence
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Biological Transport
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Brain / metabolism
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DNA, Complementary / metabolism*
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Humans
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Middle Aged
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Molecular Probes / genetics
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Molecular Sequence Data
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Neuroglia / metabolism*
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Polymorphism, Single-Stranded Conformational
Substances
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ATP-Binding Cassette Transporters
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Amino Acid Transport System X-AG
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DNA, Complementary
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Molecular Probes
Associated data
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GENBANK/S83374
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GENBANK/S83375