Abstract
Cefoxitin resistance in Klebsiella pneumoniae from Escherichia coli strains isolated in Greek hospitals was found to be due to the acquisition of similar plasmids coding for group 1 beta-lactamases. The plasmids were not self-transferable but were mobilized by conjugative plasmids. These elements have also been spread to Enterobacter aerogenes. The most common enzyme was a Citrobacter freundii-derived cephalosporinase (LAT-2) which differed from LAT-1 by three amino acids.
MeSH terms
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Amino Acid Sequence
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Base Sequence
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Cefoxitin / pharmacology*
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Cephamycins / pharmacology*
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Citrobacter freundii / drug effects
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Citrobacter freundii / enzymology
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Citrobacter freundii / genetics
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Conjugation, Genetic
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Cross Infection / microbiology*
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Drug Resistance, Microbial
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Enterobacter / drug effects
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Enterobacter / enzymology
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Enterobacter / genetics
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Enterobacteriaceae / drug effects*
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Enterobacteriaceae / enzymology
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Enterobacteriaceae / genetics*
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Escherichia coli / drug effects
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Escherichia coli / enzymology
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Escherichia coli / genetics
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Greece
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Penicillinase / genetics*
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Plasmids
Substances
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Cephamycins
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Cefoxitin
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Penicillinase