Abstract
A case of acute undifferentiated leukemia (AUL), accompanied by subcutaneous tumor and thymoma is reported. The analysis of immunophenotype showed that the leukemic blasts were positive for CD7, HLA-DR, CD38 and CD34 in 17.5% but negative results were obtained for other lymphoid and myeloid antigens. The leukemic blasts had a rearranged immunoglobulin heavy chain (IgH) gene and T cell receptor delta (TCR-delta) chain gene chromosomal abnormality, 47, XY, +8, t(13; 17) (q12; q21), -17, +M was observed. In general, the CR rate is low and prognosis is poor in patients with AUL. In our case, CR was not achieved by the therapy with JALSG-ALL87 protocol, but was achieved by subsequent treatment with high dose ara-C therapy and combination chemotherapy including intermediate-dose ara-C, mitoxantrone, etoposide and prednisolone.
MeSH terms
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ADP-ribosyl Cyclase
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ADP-ribosyl Cyclase 1
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Acute Disease
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Antigens, CD*
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Antigens, CD7 / analysis*
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Antigens, Differentiation / analysis*
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Chromosome Aberrations
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Chromosome Disorders
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Cytarabine / administration & dosage
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Etoposide / administration & dosage
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Gene Rearrangement
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HLA-DR Antigens / analysis*
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Humans
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Immunoglobulin Heavy Chains / genetics
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Immunophenotyping
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Leukemia / complications
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Leukemia / drug therapy
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Leukemia / immunology*
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Membrane Glycoproteins
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Mitoxantrone / administration & dosage
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N-Glycosyl Hydrolases / analysis*
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Prednisolone / administration & dosage
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Receptors, Antigen, T-Cell, gamma-delta / genetics
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Remission Induction
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Skin Neoplasms / complications
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Skin Neoplasms / drug therapy
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Skin Neoplasms / immunology*
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Thymoma / complications
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Thymoma / drug therapy
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Thymoma / immunology*
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Thymus Neoplasms / complications
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Thymus Neoplasms / drug therapy
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Thymus Neoplasms / immunology*
Substances
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Antigens, CD
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Antigens, CD7
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Antigens, Differentiation
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HLA-DR Antigens
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Immunoglobulin Heavy Chains
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Membrane Glycoproteins
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Receptors, Antigen, T-Cell, gamma-delta
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Cytarabine
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Etoposide
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Prednisolone
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Mitoxantrone
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N-Glycosyl Hydrolases
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ADP-ribosyl Cyclase
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CD38 protein, human
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ADP-ribosyl Cyclase 1