Although not an absolute requirement in most cases, there are many anesthetic and surgical advantages for using a double-lumen tube during intrathoracic operations. It is almost impossible that double-lumen tube intubation by conventional methods in patients whose glottis can not be visualized by direct laryngoscopy. We describe the previously unreported method by using The WuScope System for double-lumen endotracheal tube intubation in a patient with acromegaly and difficult airway.