Abstract
Simple changes in the chemistry, plumbing, and programming of the Siemens-CTI chemistry process control unit (CPCU) effectively double its output by enabling two back-to-back "1-pot" syntheses of 2-[18F]fluoro-2-deoxy-D-glucose in a single unit. Replacement of Kryptofix 2.2.2 with tetramethylammonium carbonate and elimination of diethyl ether from the procedure shorten synthesis time to 48 min, improve process and end-product safety, and increase end-of-synthesis yields from 37% to 52% by minimizing steps and transfer losses.
MeSH terms
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Animals
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Bridged Bicyclo Compounds, Heterocyclic / chemistry
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Chelating Agents / chemistry
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Deoxyglucose / analogs & derivatives*
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Deoxyglucose / chemical synthesis
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Fluorine Radioisotopes / chemistry*
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Fluorodeoxyglucose F18
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Isotope Labeling / methods
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Mice
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Quaternary Ammonium Compounds / chemistry
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Quaternary Ammonium Compounds / toxicity
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Radiochemistry / methods*
Substances
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Bridged Bicyclo Compounds, Heterocyclic
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Chelating Agents
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Fluorine Radioisotopes
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Quaternary Ammonium Compounds
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Fluorodeoxyglucose F18
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cryptating agent 222
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Deoxyglucose
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tetramethylammonium