Antimicrobial abietane diterpenoids from Plectranthus elegans

Phytochemistry. 1996 Feb;41(3):735-8. doi: 10.1016/0031-9422(95)00694-x.

Abstract

Two novel abietane diterpenoids have been isolated from the aerial material of Plectranthus elegans and identified as 11-hydroxy-12-oxo-7,9(11),13-abietatriene and 7 alpha,11-dihydroxy-12-methoxy-8,11,13-abietatriene. Their structures were determined through rigorous use of spectroscopic methods. Both inhibited spore germination of the fungus Cladosporium cucumerinum, in direct bioautography, at a dose of 1 microgram. The new diterpenes also inhibited the growth of Gram-positive bacteria, in the concentration range 10-40 micrograms ml-1 in broth dilution assay. No effect was observed against Gram-negative bacteria. The ecological implications of these findings are discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abietanes*
  • Anti-Bacterial Agents
  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / isolation & purification*
  • Chromatography, Thin Layer
  • Cladosporium / drug effects
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Microbial Sensitivity Tests
  • Plants / chemistry*
  • Spectrum Analysis

Substances

  • 11-hydroxy-12-oxo-7,9(11),13-abietatriene
  • 7,11-dihydroxy-12-methoxy-8,11,13-abietatriene
  • Abietanes
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Diterpenes