Abstract
As potential antiviral agents, 4'-thio-arabinonucleosides were synthesized. Methyl 3-O-benzyl-xylo-furanoside, readily obtained from D-glucose, was converted to 1,4-anhydro-4-deoxy-4-thio-arabinitol. The protection of hydroxyl groups and the Pummerer rearrangement, followed by Lewis acid induced glycosylation afforded 4'-thio-arabinonucleosides. The compounds showed anti HSV-1 activity.
MeSH terms
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology
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Arabinonucleosides / chemical synthesis*
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Arabinonucleosides / chemistry
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Arabinonucleosides / pharmacology
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Drug Design
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Glycosylation
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Herpesvirus 1, Human / drug effects
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Herpesvirus 2, Human / drug effects
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Herpesvirus 3, Human / drug effects
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Molecular Structure
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Thionucleosides / chemical synthesis*
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Thionucleosides / chemistry
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Thionucleosides / pharmacology
Substances
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Antiviral Agents
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Arabinonucleosides
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Thionucleosides