Preparation of pentofuranoside derivatives having ethynylene group and their reactions with oligodeoxyribonucleotides

K Sakagami; H Yamaga; A Ogawa; M Michida; O Mitsunobu

Preparation of pentofuranoside derivatives having ethynylene group and their reactions with oligodeoxyribonucleotides

Nucleic Acids Symp Ser. 1995:(34):41-2.

Authors

K Sakagami¹, H Yamaga, A Ogawa, M Michida, O Mitsunobu

Affiliation

¹ Department of Chemisty, College of Science and Engineering, Aoyama Gakuin University, Tokyo, Japan.

PMID: 8841542

Abstract

Furanoside derivatives having ethynylene group and related compounds were prepared. The reaction of these functionalized furanosides with oligodeoxy-ribonucleotide (21 mer, 5'-32P-GATAAGCTTGAAT TCATGGCC-3') and subsequent treatment with piperidine resulted in cleavage of the oligonucleotide.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Hydrogen-Ion Concentration
Indicators and Reagents
Molecular Structure
Oligodeoxyribonucleotides / chemistry*
Pentoses / chemical synthesis*
Pentoses / chemistry
Piperidines

Substances

Indicators and Reagents
Oligodeoxyribonucleotides
Pentoses
Piperidines
piperidine