Abstract
The in vitro activities of 12 beta-lactam agents against 100 thermophilic Campylobacter strains were tested. Beta-Lactamase production was detected in 88% of all strains tested. Clavulanic acid was the best inhibitor by susceptibility testing. The beta-lactams which displayed high levels of in vitro activity against Campylobacter isolates were imipenem, amoxicillin-clavulanic acid, and cefepime and, to a lesser degree, amoxicillin, ampicillin, and cefotaxime.
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Campylobacter coli / drug effects*
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Campylobacter coli / enzymology
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Campylobacter jejuni / drug effects*
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Campylobacter jejuni / enzymology
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Cephalosporins / pharmacology
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Clavulanic Acid
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Clavulanic Acids / pharmacology
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Enzyme Inhibitors / pharmacology*
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Microbial Sensitivity Tests
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Penicillanic Acid / analogs & derivatives
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Penicillanic Acid / pharmacology
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Penicillins / pharmacology
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Sulbactam / pharmacology
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Tazobactam
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beta-Lactam Resistance
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beta-Lactamase Inhibitors*
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beta-Lactamases / metabolism
Substances
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Anti-Bacterial Agents
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Cephalosporins
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Clavulanic Acids
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Enzyme Inhibitors
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Penicillins
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beta-Lactamase Inhibitors
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Clavulanic Acid
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Penicillanic Acid
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beta-Lactamases
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Sulbactam
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Tazobactam