Abstract
The authors present the case studies of two patients whose malignant tumors were detected with a Tc-99m labeled antifibrin monoclonal antibody (DD-3B6/22), which is specific for cross-linked fibrin. The first case was a malignant fibrous histiocytoma involving the proximal aspect of the left thigh, whereas in the second case, the patient was receiving treatment for a squamous cell carcinoma of the right mainstem bronchus. The results highlight the potential of this anti-D-dimer radiopharmaceutical for noninvasive detection of malignant tumors.
Publication types
-
Case Reports
-
Clinical Trial
-
Clinical Trial, Phase I
MeSH terms
-
Aged
-
Bronchial Neoplasms / diagnostic imaging*
-
Carcinoma, Squamous Cell / diagnostic imaging*
-
Fibrin Fibrinogen Degradation Products / immunology*
-
Histiocytoma, Benign Fibrous / diagnostic imaging*
-
Humans
-
Immunoglobulin Fab Fragments*
-
Male
-
Middle Aged
-
Pulmonary Embolism / diagnostic imaging
-
Radioimmunodetection*
-
Soft Tissue Neoplasms / diagnostic imaging*
-
Technetium*
-
Thigh
-
Thrombophlebitis / diagnostic imaging
Substances
-
Fibrin Fibrinogen Degradation Products
-
Immunoglobulin Fab Fragments
-
fibrin fragment D
-
Technetium