Paradoxical clinical deterioration despite near-complete pathological response to neoadjuvant chemotherapy for locally advanced gastro-oesophageal adenocarcinoma

Surg Oncol. 1995;4(5):277-9. doi: 10.1016/s0960-7404(10)80007-6.

Abstract

Neoadjuvant chemotherapy for proximal gastric cancer has shown promise in early clinical trials. We report on a clinical deterioration, yet near-complete pathological and radiological response to a combination of cisplatin and fluorouracil in a patient with locally-advanced gastric adenocarcinoma.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / drug therapy*
  • Adenocarcinoma / surgery
  • Antimetabolites, Antineoplastic / administration & dosage*
  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Chemotherapy, Adjuvant
  • Cisplatin / administration & dosage*
  • Deglutition Disorders / etiology
  • Esophageal Neoplasms / drug therapy*
  • Esophageal Neoplasms / surgery
  • Esophagectomy
  • Fluorouracil / administration & dosage*
  • Gastrectomy
  • Humans
  • Lymph Node Excision
  • Male
  • Middle Aged
  • Remission Induction
  • Stomach Neoplasms / drug therapy*
  • Stomach Neoplasms / surgery

Substances

  • Antimetabolites, Antineoplastic
  • Antineoplastic Agents
  • Cisplatin
  • Fluorouracil