Synthesis and biological evaluation of proline derivatives as potential angiotensin converting enzyme inhibitor

G Giugliano; P Grieco; A Ialenti; M Mottola; E Perissutti; V Santagada

Synthesis and biological evaluation of proline derivatives as potential angiotensin converting enzyme inhibitor

Boll Soc Ital Biol Sper. 1996 Jan-Feb;72(1-2):29-36.

Authors

G Giugliano¹, P Grieco, A Ialenti, M Mottola, E Perissutti, V Santagada

Affiliation

¹ Dipartimento di Chimica Farmaceutica e Tossicologica, Università degli Studi di Napoli.

PMID: 8868112

Abstract

The synthesis of a series of proline derivatives (1a-e and 2a-b) as pure isomers is described. These compounds were evaluated in vitro for their ability to inhibit angiotensin converting enzyme (ACE) and compared to the potency of captopril taken as a reference drug. They showed only a weak ACE inhibitory activity.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Angiotensin-Converting Enzyme Inhibitors / chemistry*
Angiotensin-Converting Enzyme Inhibitors / pharmacology
Molecular Structure
Oligopeptides / metabolism
Proline / analogs & derivatives*
Proline / pharmacology
Structure-Activity Relationship

Substances

Angiotensin-Converting Enzyme Inhibitors
Oligopeptides
hippuryl-histidyl-leucine
Proline