Abstract
The TATA-binding protein (TBP)-associated factors (TAFs) of TFIID play a central role in RNA polymerase II transcriptional regulation. Some TAFs can function as co-activators that mediate the activation signal from enhancer-bound regulators. In addition, interactions between selected TAFs and core elements direct promoter selectivity by RNA polymerase II.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism
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Models, Genetic
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Promoter Regions, Genetic*
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RNA Polymerase II / genetics
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RNA Polymerase II / metabolism
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TATA Box
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TATA-Box Binding Protein
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Trans-Activators / genetics
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Trans-Activators / metabolism
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Transcription Factor TFIID
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Transcription Factors / genetics
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Transcription Factors / metabolism*
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Transcriptional Activation*
Substances
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DNA-Binding Proteins
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TATA-Box Binding Protein
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Trans-Activators
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Transcription Factor TFIID
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Transcription Factors
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RNA Polymerase II