Abstract
Dicarbanonaborates inhibit the mitochondrial cytochrome c oxidase activity. In contrast to mitochondrial ATPase or glycerol phosphate dehydrogenase, inhibition of cytochrome c oxidase was not competitive and the residual, drug-insensitive activity was higher. These results indicate that dicarbanonaborates inhibit various mitochondrial membrane-bound enzymes through different mechanisms.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adenosine Triphosphatases / antagonists & inhibitors
-
Animals
-
Borates / pharmacology*
-
Electron Transport Complex IV / antagonists & inhibitors*
-
Glycerolphosphate Dehydrogenase / antagonists & inhibitors
-
Mitochondria, Liver / drug effects*
-
Mitochondria, Liver / enzymology
-
Rats
Substances
-
Borates
-
Glycerolphosphate Dehydrogenase
-
Electron Transport Complex IV
-
Adenosine Triphosphatases