Abstract
Only gamma-chain T-cell receptor transcripts utilizing V-1 subgroup gene segments were found in peripheral blood lymphocytes from a patient with Omenn's syndrome. gamma-Chain T-cell receptor transcripts utilizing the V gamma 9 (V-II subgroup) gene segment were absent in peripheral blood lymphocytes from this patient. V gamma 9 J gamma 1.2 C gamma 1 rearrangements are those primarily found in peripheral blood lymphocytes (70 to 85%) from normal donors.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Eosinophilia / genetics
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Gene Rearrangement, T-Lymphocyte / genetics*
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Histiocytic Sarcoma / genetics
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Humans
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Infant
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Lymphatic Diseases / genetics
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Receptors, Antigen, T-Cell, gamma-delta / genetics*
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Receptors, Antigen, T-Cell, gamma-delta / isolation & purification
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Severe Combined Immunodeficiency / genetics*
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Severe Combined Immunodeficiency / immunology*
Substances
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Receptors, Antigen, T-Cell, gamma-delta