Abstract
In a randomized, double-blind trial, gamma radiation-sterilized, chlorhexidine-coated triple-lumen catheters were compared with uncoated control catheters for their ability to prevent catheter infection in 254 intensive care unit patients. The chlorhexidine coating was not efficacious, and a rabbit model demonstrated that reduction of chlorhexidine activity by gamma radiation sterilization was the likely explanation for the failure.
Publication types
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Clinical Trial
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Multicenter Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacteremia / microbiology
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Bacteremia / prevention & control
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Catheterization / adverse effects*
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Catheterization / instrumentation*
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Chlorhexidine / pharmacology*
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Critical Care*
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Cross Infection / blood
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Cross Infection / microbiology
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Cross Infection / prevention & control*
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Disinfectants / pharmacology*
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Double-Blind Method
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Gamma Rays
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Humans
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Sterilization / methods*
Substances
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Disinfectants
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Chlorhexidine