SRS-A antagonist pyranoquinolone alkaloids from east African Fagara plants and their synthesis

T Kamikawa; Y Hanaoka; S Fujie; K Saito; Y Yamagiwa; K Fukuhara; I Kubo

doi:10.1016/0968-0896(96)00110-1

SRS-A antagonist pyranoquinolone alkaloids from east African Fagara plants and their synthesis

Bioorg Med Chem. 1996 Aug;4(8):1317-20. doi: 10.1016/0968-0896(96)00110-1.

Authors

T Kamikawa¹, Y Hanaoka, S Fujie, K Saito, Y Yamagiwa, K Fukuhara, I Kubo

Affiliation

¹ Department of Chemistry, Faculty of Science and Technology, Kinki University, Osaka.

PMID: 8879553
DOI: 10.1016/0968-0896(96)00110-1

Abstract

Three pyranoquinolone alkaloids isolated from two East African Fagara plants have been found to exhibit SRS-A antagonist action. Their synthesis has been accomplished, using a modified Coppola's method or a thermal cyclization followed by an electrocyclic ring closure.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

4-Quinolones
Africa, Eastern
Alkaloids / chemistry*
Anti-Infective Agents / chemistry*
Chromatography, Thin Layer
Plant Extracts / chemistry*
SRS-A / antagonists & inhibitors*
Spectrophotometry, Infrared
Trees / chemistry*

Substances

4-Quinolones
Alkaloids
Anti-Infective Agents
Plant Extracts
SRS-A