Regression of AIDS-related Kaposi's sarcoma during therapy with thalidomide

Clin Infect Dis. 1996 Sep;23(3):501-3; discussion 504-5. doi: 10.1093/clinids/23.3.501.

Abstract

A 14-year-old girl with HIV infection and subcutaneous Kaposi's sarcoma (KS) received thalidomide therapy for oral ulcers, resulting in regression of KS lesions, disappearance of KS-associated herpesvirus (KSHV) DNA from blood, and reduced viral load in tumor tissue. Administration of grauntocyte colony-stimulating factor resulted in clinical exacerbation of KS and reappearance of KSHV DNA in blood.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • DNA, Viral / blood
  • Female
  • Granulocyte Colony-Stimulating Factor / therapeutic use
  • HIV Infections / complications
  • HIV Infections / congenital
  • HIV Infections / immunology*
  • Herpesvirus 8, Human / isolation & purification*
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Remission Induction
  • Sarcoma, Kaposi / drug therapy*
  • Sarcoma, Kaposi / etiology
  • Sarcoma, Kaposi / immunology
  • Thalidomide / therapeutic use*
  • Viral Load

Substances

  • DNA, Viral
  • Immunosuppressive Agents
  • Granulocyte Colony-Stimulating Factor
  • Thalidomide