Abstract
We report nine cases where fluoxetine (FX) (20 mg/day) was added to maintenance treatment with methadone (MTD) (dose range: 30-100 mg) in addicts with affective disorders. MTD plasma levels were measured before and after treatment with FX under steady-state conditions. Among the nine patients, two also received fluvoxamine (FLVX) at different times. Although it is possible that in some patients a moderate FX-MTD interaction occurs, resulting in increased plasma levels of MTD, this interaction is certainly less marked than that between FLVX and MTD and unlikely to have clinical consequences.
Publication types
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Case Reports
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Comparative Study
MeSH terms
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Adult
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Analgesics, Opioid / pharmacokinetics*
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Antidepressive Agents, Second-Generation / pharmacokinetics*
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Drug Interactions
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Female
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Fluoxetine / administration & dosage
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Fluoxetine / pharmacokinetics*
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Fluvoxamine / administration & dosage
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Fluvoxamine / pharmacokinetics
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Humans
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Male
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Methadone / administration & dosage
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Methadone / pharmacokinetics*
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Mood Disorders / blood*
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Mood Disorders / drug therapy
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Selective Serotonin Reuptake Inhibitors / pharmacokinetics
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Substance-Related Disorders / blood*
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Substance-Related Disorders / rehabilitation
Substances
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Analgesics, Opioid
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Antidepressive Agents, Second-Generation
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Serotonin Uptake Inhibitors
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Fluoxetine
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Fluvoxamine
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Methadone