Abstract
Non-granulomatous nodular accumulations of inflammatory cells in inflammatory myopathies were studied to characterize adhesion mechanisms used for leukocyte recruitment. The nodules had a B-cell-rich center surrounded by a helper T-cell-rich peripheral zone, resembling lymph nodes. The T-cell-rich zones harbored high-walled venules resembling high endothelial venules (HEV), whose endothelia frequently expressed ICAM-1, VCAM-1, and less constantly E-selectin. This endothelial adhesion molecule profile differs from that found in polymyositis, inclusion body myositis, or dermatomyositis, but resembles that in lymphoid tissues. Also, the peripheral lymph node addressin, a vascular addressin specific for peripheral lymphoid tissue HEV, was present on many HEV. This adhesion system is probably responsible for the excessive lymphocyte recruitment. The similar cellular organization and lymphocyte recirculation mechanisms of the nodular infiltrates in muscle and of lymph nodes suggest that the former may also produce antibodies.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Aged
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Antibodies, Monoclonal
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Antigens, CD / analysis
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Antigens, CD / immunology
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Antigens, Differentiation, B-Lymphocyte / analysis
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Antigens, Differentiation, B-Lymphocyte / immunology
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Antigens, Surface / analysis
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Antigens, Surface / immunology
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Appendix / chemistry
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Appendix / pathology
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CD3 Complex / analysis
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CD4-Positive T-Lymphocytes / chemistry
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CD56 Antigen / analysis
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CD56 Antigen / immunology
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CD8-Positive T-Lymphocytes / chemistry
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Cell Adhesion Molecules / analysis*
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E-Selectin / analysis
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E-Selectin / immunology
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Female
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Fluorescent Antibody Technique
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Humans
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Intercellular Adhesion Molecule-1 / analysis
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Intercellular Adhesion Molecule-1 / immunology
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Lectins*
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Lymph Nodes / chemistry*
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Lymph Nodes / pathology
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Macrophages / chemistry
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Male
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Membrane Proteins
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Middle Aged
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Muscle, Skeletal / pathology
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Myositis / immunology*
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Myositis / pathology*
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Palatine Tonsil / chemistry*
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Palatine Tonsil / pathology
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Receptors, Lymphocyte Homing / analysis
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Sialic Acid Binding Ig-like Lectin 2
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Vascular Cell Adhesion Molecule-1 / analysis
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Vascular Cell Adhesion Molecule-1 / immunology
Substances
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Antibodies, Monoclonal
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Antigens, CD
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Antigens, Differentiation, B-Lymphocyte
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Antigens, Surface
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CD22 protein, human
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CD3 Complex
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CD56 Antigen
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Cell Adhesion Molecules
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E-Selectin
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L-selectin counter-receptors
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Lectins
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Membrane Proteins
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Receptors, Lymphocyte Homing
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Sialic Acid Binding Ig-like Lectin 2
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Vascular Cell Adhesion Molecule-1
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Intercellular Adhesion Molecule-1