Sequence analysis of the glycoprotein 120 coding region of a new human immunodeficiency virus type 1 subtype G strain from Russia

AIDS Res Hum Retroviruses. 1996 Sep 20;12(14):1385-8. doi: 10.1089/aid.1996.12.1385.

Abstract

PIP: This paper reports the sequencing of HIV-1 subtype G from the blood sample of a 39-year-old Russian male taken in November 1992. The heterosexual, White male and his wife living in Uzbekistan found in 1991 that they were infected with HIV-1. The man reported living in Mozambique during 1984-85 where he had no sexual relations with African residents, yet was admitted to the hospital on several occasions. However, in 1986-87, shortly after returning to the Soviet Union, he reported having a sexual relationship with a woman other than his wife. That woman and her husband were also found to be HIV-positive in 1991. The subject died in November 1993, and his wife in March 1995. His peripheral blood mononuclear cells were separated and kept at -70 degrees Celsius until used. When the blood sample was obtained, the man had a CD4 count of 10 cells/mcl, had lost more than 10% of his weight, and developed candidal esophagitis and chronic diarrhea associated with Cryptosporidia.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • HIV Envelope Protein gp120 / chemistry
  • HIV Envelope Protein gp120 / genetics*
  • HIV-1 / genetics*
  • Humans
  • Molecular Sequence Data
  • Phylogeny
  • Polymerase Chain Reaction
  • Russia

Substances

  • HIV Envelope Protein gp120

Associated data

  • GENBANK/U33095
  • GENBANK/U33096