Structure-based design of HIV protease inhibitors: sulfonamide-containing 5,6-dihydro-4-hydroxy-2-pyrones as non-peptidic inhibitors

J Med Chem. 1996 Oct 25;39(22):4349-53. doi: 10.1021/jm960541s.
No abstract available

MeSH terms

  • Crystallography, X-Ray
  • Drug Design
  • HIV Protease Inhibitors / chemical synthesis*
  • Models, Molecular
  • Protein Conformation
  • Pyrones / chemistry*
  • Stereoisomerism
  • Sulfonamides / chemistry*

Substances

  • HIV Protease Inhibitors
  • Pyrones
  • Sulfonamides