Bleb rupture following filtering surgery with mitomycin-C: clinicopathologic correlations

Ophthalmic Surg Lasers. 1996 Oct;27(10):876-7.

Abstract

A 91-year-old woman with a complete rupture of her mitomycin-C filtration bleb associated with eye rubbing while crying was examined. An 18mm soft contact lens was placed preoperatively to re-form the anterior chamber and the patient underwent a conjunctival advancement. Histopathology of the free conjunctival specimen revealed a stratified squamous epithelium with marked attentuation of the subepithelial tissue in the area treated with mitomycin-C. Bleb rupture may be associated with minimal physical trauma following guarded filtration surgery. Successful visual rehabilitation is possible with conjunctival advancement, yet long-term survival of the bleb is poor.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Antibiotics, Antineoplastic / therapeutic use*
  • Combined Modality Therapy
  • Conjunctiva / injuries*
  • Conjunctiva / pathology
  • Female
  • Filtering Surgery*
  • Glaucoma / therapy*
  • Humans
  • Massage / adverse effects*
  • Mitomycin / therapeutic use*
  • Rupture
  • Surgical Wound Dehiscence / etiology
  • Surgical Wound Dehiscence / pathology*
  • Surgical Wound Dehiscence / therapy

Substances

  • Antibiotics, Antineoplastic
  • Mitomycin