UCLA liver transplantation: analysis of immunological factors affecting outcome

Artif Organs. 1996 Oct;20(10):1063-72. doi: 10.1111/j.1525-1594.1996.tb00642.x.

Abstract

From 1988 to 1993, UCLA completed 938 first and 1,146 total orthotopic liver transplants (OLT). Race analysis demonstrated a 1-year patient survival of 89% in Blacks (n = 45) versus 80% in Whites (n = 492, p < 0.02), with no significant difference shown between Hispanics (n = 278) and Whites. The 1-year patient survival in Asians was 50% (n = 58, p < 0.02 vs. Whites) even when hepatitis B was excluded (59%, n = 43). The 1-year patient survival of hepatitis B surface antigen positive Asians (n = 15) was only 21% (p < 0.02 vs. all others). OLT patients whose panel reactive antibody (PRA) was < 10% (n = 339) demonstrated no graft or patient survival advantage versus recipients whose PRA was > 10% (n = 71). A positive antidonor flow cytometry crossmatch (> 30 mean channel shifts, n = 76) was associated with a decreased 1-year graft survival (56% vs. 73%, p < 0.05) when compared to flow negative recipients (n = 185). Graft survival for 0 DR mismatches was 74% at 1 year compared with 57% for 1 DR mismatches (p < 0.02) and 59% for 2 DR mismatches (p < 0.02).

Publication types

  • Clinical Trial
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antibody Specificity
  • Asian People
  • Azathioprine / administration & dosage
  • Azathioprine / pharmacology
  • Azathioprine / therapeutic use
  • Child
  • Child, Preschool
  • Cohort Studies
  • Cyclosporine / administration & dosage
  • Cyclosporine / pharmacology
  • Cyclosporine / therapeutic use
  • Flow Cytometry
  • Graft Rejection / drug therapy
  • Graft Rejection / prevention & control
  • Hepatitis B Surface Antigens
  • Hispanic or Latino
  • Humans
  • Immunosuppressive Agents / administration & dosage
  • Immunosuppressive Agents / pharmacology
  • Immunosuppressive Agents / therapeutic use*
  • Infant
  • Infant, Newborn
  • Liver Transplantation* / adverse effects
  • Liver Transplantation* / immunology
  • Liver Transplantation* / mortality
  • Postoperative Complications / prevention & control
  • Prospective Studies
  • Steroids / administration & dosage
  • Steroids / pharmacology
  • Steroids / therapeutic use
  • Tacrolimus / administration & dosage
  • Tacrolimus / pharmacology
  • Tacrolimus / therapeutic use*
  • White People

Substances

  • Hepatitis B Surface Antigens
  • Immunosuppressive Agents
  • Steroids
  • Cyclosporine
  • Azathioprine
  • Tacrolimus