Abstract
The synthesis, antihyperlipaemic evaluation and quantitative structure-activity relationships (QSAR) of two series of thieno[3,2-d]pyrimidin-4-one derivatives are reported. While most of the compounds in these series were found to exhibit antihyperlipaemic activity, the QSAR study of these two series indicated a positive influence of only the electronic nature of the 2-substitutents on the biological activity. The lipophilic and the steric parameters did not appear to be significant.
MeSH terms
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Animals
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Chemical Phenomena
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Chemistry, Physical
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Cholesterol / blood
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Chromatography, High Pressure Liquid
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Hypolipidemic Agents / chemical synthesis*
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Hypolipidemic Agents / pharmacology*
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Indicators and Reagents
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Molecular Conformation
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Pyrimidines / chemical synthesis*
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Pyrimidines / pharmacology
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Rats
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Rats, Wistar
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Regression Analysis
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Spectrophotometry, Infrared
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Structure-Activity Relationship
Substances
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Hypolipidemic Agents
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Indicators and Reagents
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Pyrimidines
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Cholesterol