We describe two cases of multifocal posterior exudative lesions accompanied by non-rhegmatogenous retinal detachment and massive choroidal detachment. The fluorescein angiogram in both cases showed multiple hyperfluorescent areas in the posterior pole, which resolved following repeated dye-laser photocoagulation. The reported cases are compatible with the clinical features of either multifocal posterior pigment epitheliopathy or uveal effusion, or both. The presence of choroidal detachments and resistance against photocoagulation therapy suggest that the initial lesions occurred in the choroid as well as in the retinal pigment epithelium. We conclude that the two clinical nosologic diseases represent the variable clinical expression of a single disorder.