Abstract
Ten children with newly diagnosed medulloblastoma/primitive neuroectodermal tumor of the posterior fossa were treated with total surgical resection, radiation therapy, and ICE chemotherapy regimen with ifosfamide (900 mg/m2, days 1-5), cisplatin (20 mg/m2, days 1-5), and etoposide (60 mg/m2, days 1-5) every 4 weeks for eight cycles. Four children under 2 years old were at first treated with eight cycles of ICE chemotherapy, and then irradiated. The ICE regimen was well tolerated by all children, with no irreversible adverse effects. However, dose reductions during the eight cycles were inevitable mainly due to myelosuppression. Complete remissions were achieved in eight of 10 patients at 1 month after completion of the treatment. One child showed recurrence 21 months after complete remission. The disease-free survival rate was 70% with a mean observation period of 24 months after surgery. The ICE regimen is a useful treatment modality for children with medulloblastoma. Further study is warranted to clarify long-term outcome in a number of patients.
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / adverse effects
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Bone Marrow Diseases / chemically induced
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Carboplatin / administration & dosage
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Carboplatin / adverse effects
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Cerebellar Neoplasms / drug therapy
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Cerebellar Neoplasms / radiotherapy
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Cerebellar Neoplasms / surgery
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Cerebellar Neoplasms / therapy*
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Chemotherapy, Adjuvant
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Child
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Child, Preschool
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Combined Modality Therapy
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Cranial Fossa, Posterior*
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Cranial Irradiation* / adverse effects
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Disease-Free Survival
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Etoposide / administration & dosage
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Etoposide / adverse effects
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Female
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Hearing Loss / chemically induced
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Humans
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Ifosfamide / administration & dosage
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Ifosfamide / adverse effects
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Infant
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Magnetic Resonance Imaging
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Male
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Medulloblastoma / drug therapy
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Medulloblastoma / radiotherapy
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Medulloblastoma / surgery
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Medulloblastoma / therapy*
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Neuroectodermal Tumors, Primitive / drug therapy
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Neuroectodermal Tumors, Primitive / radiotherapy
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Neuroectodermal Tumors, Primitive / surgery
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Neuroectodermal Tumors, Primitive / therapy*
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Pilot Projects
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Radiotherapy, Adjuvant
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Remission Induction
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Skull Base Neoplasms / drug therapy
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Skull Base Neoplasms / radiotherapy
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Skull Base Neoplasms / surgery
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Skull Base Neoplasms / therapy*
Substances
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Etoposide
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Carboplatin
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Ifosfamide