Calcium ionophore A 23187 induces apoptotic cell death in rat thymocytes

Cancer Lett. 1996 Oct 1;107(1):97-103. doi: 10.1016/0304-3835(96)04349-2.

Abstract

Apoptotic cell death was induced in rat thymocytes on exposure to calcium ionophore A 23187 (100 micron(s)) for 24 h as observed from morphological changes and DNA fragmentation into oligonucleosomal ladder. The cell death was independent of de novo syntheses of protein. However, the involvement of c-Myc, c-Jun, poly ADPR polymerase and antioxidant enzymes CuZn SOD and catalase was observed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis* / physiology
  • Benzamides / pharmacology
  • Calcimycin / pharmacology*
  • Cycloheximide / pharmacology
  • Enzyme Inhibitors / pharmacology
  • Ionophores / pharmacology*
  • Protein Synthesis Inhibitors / pharmacology
  • Rats
  • Rats, Sprague-Dawley
  • Thymus Gland / cytology
  • Thymus Gland / drug effects*
  • Zinc / pharmacology

Substances

  • Benzamides
  • Enzyme Inhibitors
  • Ionophores
  • Protein Synthesis Inhibitors
  • Calcimycin
  • 3-aminobenzamide
  • Cycloheximide
  • Zinc