Potent and selective thrombin inhibitors incorporating the constrained arginine mimic l-3-piperidyl(N-guanidino)alanine at P1

J Med Chem. 1996 Nov 8;39(23):4527-30. doi: 10.1021/jm960607j.
No abstract available

MeSH terms

  • Animals
  • Antithrombins / chemistry*
  • Binding Sites
  • Chromatography, High Pressure Liquid
  • Guanidines / chemistry*
  • Humans
  • Piperidines / chemistry*
  • Rats
  • Stereoisomerism
  • Thrombin / chemistry

Substances

  • Antithrombins
  • Guanidines
  • Piperidines
  • alpha-((1-aminoiminopiperidin-3-yl)methyl)-N-(2-(3-benzylsulfonamido-2-oxopiperidin-1-yl)-1-oxoethyl)glycinal
  • Thrombin