Anaplastic large-cell lymphoma (Ki-1 lymphoma) with expression of IL-5 mRNA and eosinophilic invasion

Acta Haematol. 1996;96(4):245-8. doi: 10.1159/000203793.

Abstract

We examined a patient with anaplastic large-cell lymphoma (Ki-1 lymphoma) showing eosinophilic invasion of the tumor tissues. The number of eosinophils in the peripheral blood changed as a function of the stage of the disease. The IL-5 gene was expressed in the tumor tissues, suggesting that the eosinophilic invasion and eosinophilia were caused by IL-5 derived from the lymphoma cells.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Cisplatin / administration & dosage
  • Cyclophosphamide / administration & dosage
  • Doxorubicin / administration & dosage
  • Doxorubicin / analogs & derivatives
  • Eosinophilia / complications*
  • Eosinophilia / genetics
  • Fatal Outcome
  • Humans
  • Immunosuppressive Agents / administration & dosage
  • Interleukin-5 / genetics*
  • Lymphoma, Large-Cell, Anaplastic / complications*
  • Lymphoma, Large-Cell, Anaplastic / drug therapy
  • Lymphoma, Large-Cell, Anaplastic / pathology
  • Male
  • Prednisolone / administration & dosage

Substances

  • Antineoplastic Agents
  • Immunosuppressive Agents
  • Interleukin-5
  • Doxorubicin
  • Cyclophosphamide
  • Prednisolone
  • pirarubicin
  • Cisplatin