Abstract
A series of 6-(substituted oxyethyl)penem esters having the (5S) stereochemistry which are potent inhibitors of Escherichia coli leader peptidase is described. Structure-activity relationships are discussed.
MeSH terms
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / chemistry*
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Enzyme Inhibitors / pharmacology*
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Escherichia coli / enzymology*
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Lactams / chemical synthesis
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Lactams / chemistry*
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Lactams / pharmacology*
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Membrane Proteins*
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Serine Endopeptidases / drug effects*
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Structure-Activity Relationship
Substances
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Enzyme Inhibitors
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Lactams
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Membrane Proteins
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allyl 6-(1'-acetoxyethyl)penem-3-carboxylate
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allyl 6-(1'-hydroxyethyl)penem-3-carboxylate
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Serine Endopeptidases
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type I signal peptidase