The purpose of this study was to test the applicability of exercise echocardiography in the diagnosis of coronary artery disease. The results were compared to findings of coronary angiography. 118 patients, 100 males and 18 females, who were all referred to coronary angiography for suspected ischaemic heart disease, underwent exercise echocardiography using a cycle ergometer. At coronary angiography 108 patients had significant stenosis in at least one coronary artery. Ten patients had angiographically normal coronary arteries. A new or increased wall motion abnormality detected by echocardiography after the exercise was considered an ischaemic response. Of the 108 patients with coronary artery disease, 101 had abnormal exercise echocardiograms, and the overall sensitivity of exercise echocardiography in detecting ischaemic heart disease was 94%. Among the 10 patients without coronary artery disease, seven had normal and three had abnormal exercise echocardiograms, and the specificity of the test was 70%. In conclusion, exercise echocardiography is a reliable diagnostic method in screening of ischaemic heart disease, and it can be combined relatively easily with the exercise examinations.