Adenosine and the nervous system: clinical implications

Clin Neuropharmacol. 1996 Dec;19(6):459-74. doi: 10.1097/00002826-199619060-00001.

Abstract

After a review of the metabolism and pharmacology of adenosine, this work will examine the various therapeutic possibilities involving the use of agonists or antagonists of adenosine A1 or A2 receptors in neurological disorders. Promising preclinical results have been obtained with epilepsy, cerebral ischemia, alcoholism, and pain.

Publication types

  • Review

MeSH terms

  • Adenosine / metabolism
  • Adenosine / pharmacology
  • Adenosine / physiology*
  • Animals
  • Humans
  • Nervous System / drug effects
  • Nervous System / metabolism
  • Nervous System Physiological Phenomena*
  • Purinergic P1 Receptor Agonists
  • Purinergic P1 Receptor Antagonists

Substances

  • Purinergic P1 Receptor Agonists
  • Purinergic P1 Receptor Antagonists
  • Adenosine