Antiinflammatory effect of petroleum ether extract of leaves of Litchi chinensis Gaertn. (Sapindaceae)

J Ethnopharmacol. 1996 Oct;54(1):1-6. doi: 10.1016/0378-8741(96)01440-7.

Abstract

Pharmacological studies were conducted with the petroleum ether extract of leaves of the plant Litchi chinensis Gaertn. (Sapindaceae) on experimental animals. The extract was found to possess antiinflammatory, analgesic and antipyretic activity. Acute toxicity studies revealed that the extract, up to a dose of 1 g/kg intraperitoneally, was nontoxic. The extract did not inhibit arachidonic acid-induced paw inflammation thus indicating that it may inhibit the cyclooxygenase pathway of arachidonic acid metabolism. The extract also enhanced peritoneal cell exudate along with macrophage significantly.

Publication types

  • Comparative Study

MeSH terms

  • Analgesics / administration & dosage
  • Analgesics / pharmacology*
  • Analgesics / therapeutic use
  • Analgesics, Non-Narcotic / administration & dosage
  • Analgesics, Non-Narcotic / pharmacology*
  • Analgesics, Non-Narcotic / therapeutic use
  • Animals
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / pharmacology*
  • Anti-Inflammatory Agents / therapeutic use
  • Arachidonic Acid / metabolism
  • Arachidonic Acid / toxicity
  • Carrageenan / administration & dosage
  • Carrageenan / toxicity
  • Croton Oil / administration & dosage
  • Croton Oil / toxicity
  • Cyclooxygenase Inhibitors / administration & dosage
  • Cyclooxygenase Inhibitors / pharmacology
  • Cyclooxygenase Inhibitors / therapeutic use
  • Disease Models, Animal
  • Ear Diseases / chemically induced
  • Ear Diseases / drug therapy
  • Edema / chemically induced
  • Edema / drug therapy
  • Injections, Intraperitoneal
  • Macrophages, Peritoneal / cytology
  • Macrophages, Peritoneal / drug effects
  • Mice
  • Mice, Inbred BALB C
  • Pain / drug therapy
  • Petroleum
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Plant Leaves / metabolism*
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents
  • Cyclooxygenase Inhibitors
  • Petroleum
  • Plant Extracts
  • Arachidonic Acid
  • Croton Oil
  • Carrageenan