Abstract
Objective:
In this study the authors evaluated the efficacy and the tolerability of sertraline and paroxetine in the treatment of delusional depression.
Method:
Under double-blind conditions, 46 hospitalized patients who met the DSM-III-R criteria for major depression with psychotic features were treated with sertraline or paroxetine for 6 weeks.
Results:
The response rates were 75% and 46% for sertraline and paroxetine, respectively. The dropout rate was substantial (41%) in the paroxetine group and was attributable to side effects.
Conclusions:
Selective serotonin reuptake inhibitors administered alone are useful in the treatment of delusional depression.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
MeSH terms
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1-Naphthylamine / administration & dosage
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1-Naphthylamine / analogs & derivatives*
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1-Naphthylamine / therapeutic use
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Delusions / drug therapy*
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Delusions / psychology
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Depressive Disorder / drug therapy*
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Depressive Disorder / psychology
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Dose-Response Relationship, Drug
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Double-Blind Method
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Drug Administration Schedule
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Female
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Hospitalization
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Humans
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Male
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Middle Aged
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Paroxetine / administration & dosage
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Paroxetine / therapeutic use*
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Selective Serotonin Reuptake Inhibitors / administration & dosage
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Selective Serotonin Reuptake Inhibitors / therapeutic use*
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Sertraline
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Treatment Outcome
Substances
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Serotonin Uptake Inhibitors
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Paroxetine
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1-Naphthylamine
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Sertraline