Abstract
alpha1-Antitrypsin, an acute-phase reactant in many species, protects significantly against the lethality induced by TNF or endotoxin in mice. The protection is optimal with a single dose of at least 300 microg i.p. or 100 microg i.v. given 2 h before a lethal challenge, either with a low dose of TNF in the presence of galactosamine or a higher dose of murine TNF alone. Under optimal conditions, the drop in body temperature, the release of liver transaminases, and the increase in clotting time are also inhibited. alpha1-Antitrypsin does not protect against a lethal dose of platelet-activating factor. It is suggested that the protection is due to reduced release of platelet-activating factor.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alanine Transaminase / blood
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Animals
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Aspartate Aminotransferases / blood
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Blood Coagulation / drug effects
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Body Temperature / drug effects
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Drug Interactions
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Female
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Galactosamine / administration & dosage
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Liver / drug effects
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Liver / enzymology
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Mice
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Mice, Inbred C57BL
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Platelet Activating Factor / metabolism
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Tumor Necrosis Factor-alpha / administration & dosage
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Tumor Necrosis Factor-alpha / antagonists & inhibitors*
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Tumor Necrosis Factor-alpha / toxicity*
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alpha 1-Antitrypsin / administration & dosage
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alpha 1-Antitrypsin / pharmacology*
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alpha 1-Antitrypsin / physiology
Substances
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Platelet Activating Factor
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Tumor Necrosis Factor-alpha
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alpha 1-Antitrypsin
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Galactosamine
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Aspartate Aminotransferases
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Alanine Transaminase