Abstract
Specific families of transcription factors mediate events in the sequential maturation of distinct neuronal phenotypes. Members of one such family, the class IV POU domain transcription factor Brn-3.0, and two highly related factors Brn-3.1 and Brn-3.2, are differentially expressed in the developing and mature mammalian nervous system. The expression pattern of Brn-3.0 suggested that it has an important role in the development of sensory ganglia, as well as red nucleus, inferior olive, and nucleus ambiguus. Analysis of mice null for the Brn-3.0 locus shows that Brn-3.0 is required for the survival of subpopulations of proprioceptive, mechanoreceptive and nociceptive sensory neurons, where deletion of the gene affects neurotrophin and neurotrophin-receptor gene expression. Deletion of Brn-3.0 also alters either differentiation, migration or survival of specific central neuronal populations.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Brain-Derived Neurotrophic Factor / genetics
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Cell Differentiation
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Cell Survival
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DNA-Binding Proteins / genetics*
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DNA-Binding Proteins / physiology
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Ganglia, Sensory / cytology
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Ganglia, Sensory / embryology
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Ganglia, Sensory / metabolism
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Gene Expression
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Gene Targeting
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Medulla Oblongata / embryology
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Medulla Oblongata / growth & development
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Medulla Oblongata / metabolism
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Mice
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Motor Neurons / cytology*
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Motor Neurons / metabolism
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Nerve Growth Factors / physiology
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Neurons, Afferent / cytology*
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Neurons, Afferent / metabolism
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Olivary Nucleus / embryology
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Olivary Nucleus / growth & development
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Olivary Nucleus / metabolism
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Receptor Protein-Tyrosine Kinases / genetics
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Receptor, Ciliary Neurotrophic Factor
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Receptor, Nerve Growth Factor
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Receptor, trkC
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Receptors, Nerve Growth Factor / genetics
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Red Nucleus / embryology
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Red Nucleus / growth & development
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Red Nucleus / metabolism
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Stem Cells
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Transcription Factor Brn-3
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Transcription Factor Brn-3A
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Transcription Factors / genetics*
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Transcription Factors / physiology
Substances
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Brain-Derived Neurotrophic Factor
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DNA-Binding Proteins
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Nerve Growth Factors
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Pou4f1 protein, mouse
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Receptor, Ciliary Neurotrophic Factor
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Receptor, Nerve Growth Factor
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Receptors, Nerve Growth Factor
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Transcription Factor Brn-3
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Transcription Factor Brn-3A
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Transcription Factors
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Receptor Protein-Tyrosine Kinases
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Receptor, trkC