Abstract
The actions of THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) and ZAPA (Z-3-[(aminoiminomethyl)thio]prop-2-enoic acid) were tested on an ionotropic homo-oligomeric GABA receptor of Drosophila melanogaster. The amplitude of currents activated by THIP and ZAPA declined rapidly during agonist application and a rebound response was observed on washout. By correcting the pH shift induced by these acid salts, responses more typical of GABA agonists were seen. Less striking pH-dependence was observed in the case of GABA responses.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acrylates / pharmacology*
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Animals
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Drosophila melanogaster
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Female
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GABA Agonists / pharmacology*
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Hydrogen-Ion Concentration
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Isoxazoles / pharmacology*
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Oocytes / metabolism
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Receptors, GABA / biosynthesis
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Receptors, GABA / genetics*
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Recombinant Proteins / biosynthesis
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Xenopus
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gamma-Aminobutyric Acid / pharmacology
Substances
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Acrylates
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GABA Agonists
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Isoxazoles
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Receptors, GABA
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Recombinant Proteins
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gamma-Aminobutyric Acid
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3-((aminoiminomethyl)thio)-2-propenoic acid
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gaboxadol