Single- and multiple-dose pharmacokinetics and pharmacodynamics of leflunomide's active metabolite A77 1726 in normal Lewis rats

Transplant Proc. 1996 Dec;28(6):3092-4.
No abstract available

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Aniline Compounds / administration & dosage
  • Aniline Compounds / pharmacokinetics*
  • Aniline Compounds / pharmacology
  • Animals
  • Crotonates
  • DNA / biosynthesis
  • DNA / drug effects
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Hydroxybutyrates / administration & dosage
  • Hydroxybutyrates / pharmacokinetics*
  • Hydroxybutyrates / pharmacology
  • Immunosuppressive Agents / administration & dosage
  • Immunosuppressive Agents / pharmacokinetics*
  • Immunosuppressive Agents / pharmacology
  • Isoxazoles / administration & dosage
  • Isoxazoles / pharmacokinetics*
  • Isoxazoles / pharmacology
  • Leflunomide
  • Lymphocyte Activation / drug effects
  • Male
  • Metabolic Clearance Rate
  • Nitriles
  • Rats
  • Rats, Inbred Lew
  • Thymidine / metabolism
  • Time Factors
  • Toluidines

Substances

  • Aniline Compounds
  • Crotonates
  • Hydroxybutyrates
  • Immunosuppressive Agents
  • Isoxazoles
  • Nitriles
  • Toluidines
  • teriflunomide
  • DNA
  • Leflunomide
  • Thymidine